百度作业网英语翻译The discovery,development,and clinical use of antibiotic
来源：学生作业帮 编辑：百度作业网作业帮 分类：英语作业 时间：2024/08/12 03:50:29
英语翻译
The discovery,development,and clinical use of antibiotics during the 20th century have decreased substantially the morbidity and mortality from bacterial infections.The antibiotic era started with the therapeutic application of sulfonamide drugs in the 1930s,followed by a“golden”period of discovery from1945 to 1970,when a series of structurally diverse,highly effective antibiotics were discovered and developed[1].However,since the 1980s the introduction of new agents for clinical use has declined,reflecting both the challenge of identifying new drug classes and a declining commitment to antibacterial drug discovery by the pharmaceutical industry[2].The same period with a reduced rate of introduction of new agents has been accompanied by an alarming increase in bacterial resistance to existing agents,resulting in the emergence of a serious threat to global public health[3].
The discovery,development,and clinical use of antibiotics during the 20th century have decreased substantially the morbidity and mortality from bacterial infections.The antibiotic era started with the therapeutic application of sulfonamide drugs in the 1930s,followed by a“golden”period of discovery from1945 to 1970,when a series of structurally diverse,highly effective antibiotics were discovered and developed[1].However,since the 1980s the introduction of new agents for clinical use has declined,reflecting both the challenge of identifying new drug classes and a declining commitment to antibacterial drug discovery by the pharmaceutical industry[2].The same period with a reduced rate of introduction of new agents has been accompanied by an alarming increase in bacterial resistance to existing agents,resulting in the emergence of a serious threat to global public health[3].
20世纪期间抗生素的发现、发展到临床使用极大地降低了细菌感染的发病率和死亡率.抗生素时代以30年代中使用磺胺类药物的显著疗效开始,紧随其后的是1945-1970年期间“新发现的黄金时期”,这期间有一系列结构不同且高效的抗生素被发现并完善改进.然而,从80年代起新临床制剂的采用渐渐衰落,这反映出对发现新药物的需求以及制药业对发现抗生素药物的支持热情消减.在采用新制剂药物比率下降的同时伴随着一个令人警觉的细菌对已存在制剂抗药性的增长,从而导致了一系列威胁全球人类健康的紧急情况.
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