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the conclusion is beyond any doubt and,___thousands of peopl

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the conclusion is beyond any doubt and,___thousands of people have proved time and time again.
A:in all
B:in effect
C:for pleasure
D:for fact
选哪个?为什么?
the conclusion is beyond any doubt and,___thousands of peopl
选B.
B:in effect:事实上,实际上,比较切合题目的意思.
A:in all:总之,总共,合计,一般用与句末.
题意为:这个结论毫无疑问,成千上万的人进行了多次论证.